Risk factors for heart attack include; age, tobacco, high blood pressure, lipid profile, diabetes, family history of heart attack, lack of physical activity, obesity, stress, illicit drug use, history of preeclampsia, history of autoimmune condition such as lupus or rheumatoid arthritis and so on and so on. Why have all these risk factors been identified? Because it is better to prevent a heart attack than it is to have one. Risk factor identification and modification is the cornerstone of p...
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Clinical Laboratory
Salivary Diagnostics: Your Molecular X-Ray
According to Merriam-Webster, one of the definitions of technology is a manner of accomplishing a task especially using technical processes, methods, or knowledge. This definition rings true for the introduction of clinical laboratory testing for the health care professions. It was noted in research by the NIH, “…it was not until 1896 that the first clinical laboratory was opened, a twelve-foot-by-twelve-foot room equipped at a cost of $50 at Johns Hopkins Hospital.”1 So for over a century, ...
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My Visit to OralDNA® Labs
Have you ever wondered what happens to your patient’s saliva sample once it arrives at OralDNA® Labs? Many PDS®-supported offices have been using OralDNA® Labs to analyze the saliva of their patients, relative to the patient’s periodontal infection. This service gives them more information about the types and severity of a patient’s infection, which is the cause of periodontitis. Additionally, however, it tells us something about the bacterial load and a patient’s inflammatory response, w...
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OraRisk® Caries: Identifying Bacteria for Risk Assessment
Dental caries is defined as the progressive destruction of a tooth and is considered a major health issue in both adolescents and adults, in which reportedly 90% of the population is affected1. Cavities are formed when acid erodes the hard tissues of the teeth (enamel, dentin and cementum).
Acid is produced in the mouth when certain bacteria, such as Streptococcus mutans, ferment sugars into acid. For decades, S. mutans was believed to be the main bacteria involved in caries initiation ...
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Caries Risk Assessment Duo: The Canary System® and OraRisk® Caries
In the past, controlling or treating dental caries meant restoring all areas of decay. After which, the patient was believed to be “caries controlled” until something new developed. We now know that this thinking is flawed. Filling or restoring caries does not treat the disease, only its effects on the tooth. In 2001, the National Institute of Health defined caries as a disease resulting in the destruction of tooth structure by acid forming bacteria found in dental plaque in the presence ...
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“Test – and Retest – for Clinical Success”
Periodontal disease affects over half of the population and expresses itself differently in different people. It is a highly personalized disease. It is initiated by bacteria, yeast, and viruses that live in a layer on the teeth we refer to as biofilm. It is this biofilm that stimulates a unique host response.
INDIVIDUAL HOST RESPONSE
Each individual’s host response is dictated by combining their genetics with their acquired risk factors. Acquired risk factors are things that they can ...
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OraRisk® Caries: Identifying Bacteria for Risk Assessment
Dental caries is defined as the progressive destruction of a tooth and is considered a major health issue in both adolescents and adults, in which reportedly 90% of the population is affected(1). Cavities are formed when acid erodes the hard tissues of the teeth (enamel, dentin and cementum).
Acid is produced in the mouth when certain bacteria, such as Streptococcus mutans, ferment sugars into acid. For decades, S. mutans was believed to be the main bacteria involved in caries initiation ...
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What does it mean when the report says “QNS”?
QNS is the abbreviation for Quantity Not Sufficient or Quality Not Sufficient. When referring to molecular testing, i.e. nucleic acid or DNA based tests; a final result of QNS is given when the laboratory cannot amplify the submitted sample acceptably.
In the case of insufficient Quantity, this typically means that not enough human cells were collected or submitted in the sample to amplify the internal control for at least a negative test result. The internal control monitors sample colle...
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Patient with Chronic Gingivitis & Oral Candida
Challenge: Patient presented with chronic gingivitis and oral Candida symptoms
Background: A 64-year-old female sought treatment from a medical doctor for a “thrush-like” infection. The medical doctor then referred the patient to an ENT. However, this patient was already of our record and decided to start with our office. The chief complaint is a “thrush-like” infection in the mouth, throat and lips. The clinical assessment confirmed generalized white patches. Upon periodontal assessment,...
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Interview with Dawnie Kildoo, DDS, MAGD
Dr. McGlennen: Tell me how do you use OralDNA® salivary diagnostics.
Dr. Kildoo: We perform a MyPerioPath® on every patient with signs of periodontal disease. It gives us a more accurate diagnosis and helps us understand possible risk factors for other systemic diseases, such as Alzheimer’s, diabetes and strokes. Recently, we have been sending the results to the patient’s physician to help them understand the oral-systemic connection, too.
Dr. McGlennen: What has been the physician’s ...
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